MTHFR Gene Variants: What They Mean and How to Support Methylation
MTHFR variants affect how your body processes folate and methylates DNA — influencing everything from cardiovascular health to mood and detoxification.
MTHFR — methylenetetrahydrofolate reductase — is one of the most commonly discussed genes in functional medicine. Variants in this gene, particularly C677T and A1298C, are estimated to affect up to 40% of the population to varying degrees. Yet most people have never heard of it.
The MTHFR enzyme is central to the methylation cycle — a biochemical process that runs hundreds of times per second in your cells, influencing DNA repair, neurotransmitter production, cardiovascular health, detoxification, and immune function. When MTHFR variants reduce enzyme efficiency, the downstream effects can be wide-ranging.
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